Radioimmunoassays for Insulin, C-Peptide and Proinsulin

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Radioimmunoassays for Insulin, C-Peptide and Proinsulin by L. Heding, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: L. Heding ISBN: 9789401170949
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author: L. Heding
ISBN: 9789401170949
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES DIFFERENCES Crude insulin was extracted and isolated from dog pancreases removed 7-1 ° weeks after ligation of the pancreatic duct for the first time in 1921 by Banting and Best. Its lifesaving properties were subsequently documented in pancreatectomized dogs in 1922. Only about six months elapsed from its discovery until systematic collection of calf and ox pancreases and, later, porcine pancreases was established and the blood glucose lowering effect in diabetics using the crude extract from these glands proven. It was not until 1960, however, that the primary structure of all three species of insulin, lO7 human, porcine and bovine, was elucidated . It then became evident that the differences between bovine, porcine and human insulin amounted to at mosl 3 amino acids. These apparently small differences have a significant impact on the physico-chemical characteristics of the three insulins which again affect, e.g., the rate of absorption of insulin lO9 preparations from the subcutaneous tissue and their immunogenicity, i.e.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES DIFFERENCES Crude insulin was extracted and isolated from dog pancreases removed 7-1 ° weeks after ligation of the pancreatic duct for the first time in 1921 by Banting and Best. Its lifesaving properties were subsequently documented in pancreatectomized dogs in 1922. Only about six months elapsed from its discovery until systematic collection of calf and ox pancreases and, later, porcine pancreases was established and the blood glucose lowering effect in diabetics using the crude extract from these glands proven. It was not until 1960, however, that the primary structure of all three species of insulin, lO7 human, porcine and bovine, was elucidated . It then became evident that the differences between bovine, porcine and human insulin amounted to at mosl 3 amino acids. These apparently small differences have a significant impact on the physico-chemical characteristics of the three insulins which again affect, e.g., the rate of absorption of insulin lO9 preparations from the subcutaneous tissue and their immunogenicity, i.e.

More books from Springer Netherlands

Cover of the book On the Motives which led Husserl to Transcendental Idealism by L. Heding
Cover of the book Progress in Radiopharmacy by L. Heding
Cover of the book A New Foundation for Representation in Cognitive and Brain Science by L. Heding
Cover of the book Stem Cells and Cancer Stem Cells, Volume 6 by L. Heding
Cover of the book Design to Test by L. Heding
Cover of the book Therapeutic Problems in Pregnancy by L. Heding
Cover of the book Proceedings of the 3rd International Symposium on Orbital Disorders Amsterdam, September 5–7, 1977 by L. Heding
Cover of the book Atmospheric Measurements during POPCORN — Characterisation of the Photochemistry over a Rural Area by L. Heding
Cover of the book Is Science Progressive? by L. Heding
Cover of the book Women and Revolution by L. Heding
Cover of the book The New Bonapartist Generals in the Crimean War by L. Heding
Cover of the book Reloading Data Protection by L. Heding
Cover of the book ‘In Considerable Variety’: Introducing the Diversity of Australia’s Insects by L. Heding
Cover of the book Perspectives on Males and Singing by L. Heding
Cover of the book Weight of Modernity by L. Heding
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy