Radioimmunoassays for Insulin, C-Peptide and Proinsulin

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Radioimmunoassays for Insulin, C-Peptide and Proinsulin by L. Heding, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: L. Heding ISBN: 9789401170949
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author: L. Heding
ISBN: 9789401170949
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES DIFFERENCES Crude insulin was extracted and isolated from dog pancreases removed 7-1 ° weeks after ligation of the pancreatic duct for the first time in 1921 by Banting and Best. Its lifesaving properties were subsequently documented in pancreatectomized dogs in 1922. Only about six months elapsed from its discovery until systematic collection of calf and ox pancreases and, later, porcine pancreases was established and the blood glucose lowering effect in diabetics using the crude extract from these glands proven. It was not until 1960, however, that the primary structure of all three species of insulin, lO7 human, porcine and bovine, was elucidated . It then became evident that the differences between bovine, porcine and human insulin amounted to at mosl 3 amino acids. These apparently small differences have a significant impact on the physico-chemical characteristics of the three insulins which again affect, e.g., the rate of absorption of insulin lO9 preparations from the subcutaneous tissue and their immunogenicity, i.e.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES DIFFERENCES Crude insulin was extracted and isolated from dog pancreases removed 7-1 ° weeks after ligation of the pancreatic duct for the first time in 1921 by Banting and Best. Its lifesaving properties were subsequently documented in pancreatectomized dogs in 1922. Only about six months elapsed from its discovery until systematic collection of calf and ox pancreases and, later, porcine pancreases was established and the blood glucose lowering effect in diabetics using the crude extract from these glands proven. It was not until 1960, however, that the primary structure of all three species of insulin, lO7 human, porcine and bovine, was elucidated . It then became evident that the differences between bovine, porcine and human insulin amounted to at mosl 3 amino acids. These apparently small differences have a significant impact on the physico-chemical characteristics of the three insulins which again affect, e.g., the rate of absorption of insulin lO9 preparations from the subcutaneous tissue and their immunogenicity, i.e.

More books from Springer Netherlands

Cover of the book Global Poverty Alleviation: A Case Book by L. Heding
Cover of the book Tumours, Lymphomas and Selected Paraproteinaemias by L. Heding
Cover of the book Microbial Plant Pathogens-Detection and Disease Diagnosis: by L. Heding
Cover of the book Philosophy and Geometry by L. Heding
Cover of the book Clinical Learning and Teaching Innovations in Nursing by L. Heding
Cover of the book Climate and Weather of the Sun-Earth System (CAWSES) by L. Heding
Cover of the book Québec Studies in the Philosophy of Science by L. Heding
Cover of the book Dependency or Interdependency in Old Age by L. Heding
Cover of the book Biological Management of Diseases of Crops by L. Heding
Cover of the book Advances in Quality of Life Theory and Research by L. Heding
Cover of the book Prolegomena to a Critical Grammar by L. Heding
Cover of the book Terahertz and Mid Infrared Radiation by L. Heding
Cover of the book The calcitonin gene-related peptide family by L. Heding
Cover of the book Air-Sea Exchange: Physics, Chemistry and Dynamics by L. Heding
Cover of the book Ethics and the Will by L. Heding
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy