Radionuclide Imaging in Drug Research

Kids, Natural World, Nonfiction, Reference & Language, Education & Teaching, Science & Nature, Science
Cover of the book Radionuclide Imaging in Drug Research by , Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9789401197281
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9789401197281
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

The use of gamma-emitting radionuclides for diagnostic imaging in nuclear medicine has been established for many years. Sophisticated gamma ray detecting camera systems and computer links enable the clinical investigator to image different regions of the body and to quantify organ function. Parallel developments have also occurred in the field of radiopharmaceuticals, and today a wide range of products is available that will exhibit specific uptake within target tissues following parenteral administration. For example, radioiodide is taken up by the thyroid and iodinated fatty acids can be used to image the myocardium. Labelled antibodies have been used with success to target certain tumours. The concept of targeting has also been considered by pharmaceutical scientists who wish to deliver drugs rather than radionuclides to specific sites in the body. The systems that have been employed are often physically similar to those used as radiopharmaceuticals (for example colloids, aerosols and liposomes). Furthermore, pioneering work by Digenis and others in the United States States and by Alpsten and co-workers (1976)in Sweden had demonstrated the potential of gamma scintigraphy for investigating the fate of tablets and capsules in the gastrointestinal tract of man in a non­ invasive way. In 1979, the Biopharmaceutics Research Group at Nottingham together with academic pharmacists from Manchester held a one-day syffiposium at Nottingham University to discuss how radio­ nuclides could be used in drug formulation studies to provide better approaches for the delivery of drugs to their sitesof action.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The use of gamma-emitting radionuclides for diagnostic imaging in nuclear medicine has been established for many years. Sophisticated gamma ray detecting camera systems and computer links enable the clinical investigator to image different regions of the body and to quantify organ function. Parallel developments have also occurred in the field of radiopharmaceuticals, and today a wide range of products is available that will exhibit specific uptake within target tissues following parenteral administration. For example, radioiodide is taken up by the thyroid and iodinated fatty acids can be used to image the myocardium. Labelled antibodies have been used with success to target certain tumours. The concept of targeting has also been considered by pharmaceutical scientists who wish to deliver drugs rather than radionuclides to specific sites in the body. The systems that have been employed are often physically similar to those used as radiopharmaceuticals (for example colloids, aerosols and liposomes). Furthermore, pioneering work by Digenis and others in the United States States and by Alpsten and co-workers (1976)in Sweden had demonstrated the potential of gamma scintigraphy for investigating the fate of tablets and capsules in the gastrointestinal tract of man in a non­ invasive way. In 1979, the Biopharmaceutics Research Group at Nottingham together with academic pharmacists from Manchester held a one-day syffiposium at Nottingham University to discuss how radio­ nuclides could be used in drug formulation studies to provide better approaches for the delivery of drugs to their sitesof action.

More books from Springer Netherlands

Cover of the book The 21st Century — Turning Point for the Northern Sea Route? by
Cover of the book Airways Obstruction by
Cover of the book Advanced Łukasiewicz calculus and MV-algebras by
Cover of the book Handbook on Environmental Aspects of Fertilizer Use by
Cover of the book Nation-Building and History Education in a Global Culture by
Cover of the book Faith from a Positive Psychology Perspective by
Cover of the book Complexity, Difference and Identity by
Cover of the book A history of surgery by
Cover of the book Birds as Monitors of Environmental Change by
Cover of the book Principles of Soft-Matter Dynamics by
Cover of the book The New Rhetoric and the Humanities by
Cover of the book Advances in Quality of Life Theory and Research by
Cover of the book Clinical Laboratory Science in the Changing Scene of Health Care by
Cover of the book Methods of Cancer Diagnosis, Therapy, and Prognosis by
Cover of the book Adolescents by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy