Sendai Virus Vector

Advantages and Applications

Nonfiction, Health & Well Being, Medical, Medical Science, Microbiology, Genetics
Cover of the book Sendai Virus Vector by , Springer Japan
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9784431545569
Publisher: Springer Japan Publication: January 31, 2014
Imprint: Springer Language: English
Author:
ISBN: 9784431545569
Publisher: Springer Japan
Publication: January 31, 2014
Imprint: Springer
Language: English

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

More books from Springer Japan

Cover of the book Disaster Risk Reduction Approaches in Pakistan by
Cover of the book Geometric Aspects of General Topology by
Cover of the book Growth, Proliferation, and Apoptosis in Hepatocytes by
Cover of the book Agent-Based Approaches in Economic and Social Complex Systems VI by
Cover of the book Biomechanics in Orthopedics by
Cover of the book Non-Cooperative Game Theory by
Cover of the book Myelinated Fibers and Saltatory Conduction in the Shrimp by
Cover of the book Coronary Circulation in Physiological and Pathophysiological States by
Cover of the book Structural Analysis of Metallic Glasses with Computational Homology by
Cover of the book Human Body Odor by
Cover of the book Methods in Neuroethological Research by
Cover of the book Climate Change and Biodiversity by
Cover of the book The Smart City and the Co-creation of Value by
Cover of the book Haptic Interaction by
Cover of the book Long Noncoding RNAs by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy