Spheroid Culture in Cancer Research (1991)

Nonfiction, Health & Well Being, Medical, Specialties, Pathology, Oncology
Cover of the book Spheroid Culture in Cancer Research (1991) by Rolf Bjerkvig, CRC Press
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Author: Rolf Bjerkvig ISBN: 9781351357623
Publisher: CRC Press Publication: November 22, 2017
Imprint: CRC Press Language: English
Author: Rolf Bjerkvig
ISBN: 9781351357623
Publisher: CRC Press
Publication: November 22, 2017
Imprint: CRC Press
Language: English

Spheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined.

The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.

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Spheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined.

The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.

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