Starling’s Law of The Heart Revisited

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Cardiology
Cover of the book Starling’s Law of The Heart Revisited by , Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9789400913134
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author:
ISBN: 9789400913134
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

H. E. D. J. TER KEURS & M. I. M. NOBLE The "Starling's Law of the Heart" and "The Frank-Starling Mechanism" have long been the cornerstone of cardiac mechanical physiology. It is often forgotten that Frank and Starling carried out fundamentally different exper­ iments. Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume-volume rela­ tionship which depends directly on the force-length relationship of the 2 sarcomeres. Starling ,3 studied cardiac shortening as manifest by cardiac output and its relationship to end-diastolic conditions as manifest by right atrial pressure. Thus he was studying the ability of cardiac muscle to shorten more at a given load from a greater initial length. Starling in the promulga­ 4 tions of his law implied a common mechanism for these two phenomena and spoke of the "energy liberated" being a function of initial muscle fiber length. However, there has been much confusion about the interrelationship between the two different aspects studied by Frank and Starling. The 1960s saw the era of isolated cardiac muscle mechanics, beginning with 5 the paper of Abbott and Mommaerts. Whole muscle length-tension relations were equated with sarcomere-length-tension relations by fixation of muscle at a particular point on the curve and determination of sarcomere length by electronmicroscopy.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

H. E. D. J. TER KEURS & M. I. M. NOBLE The "Starling's Law of the Heart" and "The Frank-Starling Mechanism" have long been the cornerstone of cardiac mechanical physiology. It is often forgotten that Frank and Starling carried out fundamentally different exper­ iments. Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume-volume rela­ tionship which depends directly on the force-length relationship of the 2 sarcomeres. Starling ,3 studied cardiac shortening as manifest by cardiac output and its relationship to end-diastolic conditions as manifest by right atrial pressure. Thus he was studying the ability of cardiac muscle to shorten more at a given load from a greater initial length. Starling in the promulga­ 4 tions of his law implied a common mechanism for these two phenomena and spoke of the "energy liberated" being a function of initial muscle fiber length. However, there has been much confusion about the interrelationship between the two different aspects studied by Frank and Starling. The 1960s saw the era of isolated cardiac muscle mechanics, beginning with 5 the paper of Abbott and Mommaerts. Whole muscle length-tension relations were equated with sarcomere-length-tension relations by fixation of muscle at a particular point on the curve and determination of sarcomere length by electronmicroscopy.

More books from Springer Netherlands

Cover of the book Consumer Demographics and Behaviour by
Cover of the book Many Sides: A Protagorean Approach to the Theory, Practice and Pedagogy of Argument by
Cover of the book Professional Learning as Relational Practice by
Cover of the book Antiglobulins, cryoglobulins and glomerulonephritis by
Cover of the book The Impact of Climate Change on European Lakes by
Cover of the book Conceptual Challenges in Evolutionary Psychology by
Cover of the book Nutrition and Heart Disease by
Cover of the book Gender in Agriculture by
Cover of the book Toleration, Neutrality and Democracy by
Cover of the book The Developing Heart: A ‘History’ of Pediatric Cardiology by
Cover of the book The Likelihood of Knowledge by
Cover of the book Date Palm Genetic Resources and Utilization by
Cover of the book Sustainable Solid Waste Management in the Southern Black Sea Region by
Cover of the book From Theology to History: French Religious Controversy and the Revocation of the Edict of Nantes by
Cover of the book Probability and Causality by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy