Stereochemical Analysis of Alicyclic Compounds by C-13 NMR Spectroscopy

Nonfiction, Science & Nature, Science, Physics, Spectrum Analysis, Reference & Language, Education & Teaching
Cover of the book Stereochemical Analysis of Alicyclic Compounds by C-13 NMR Spectroscopy by J. A. Whitesell, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: J. A. Whitesell ISBN: 9789400931619
Publisher: Springer Netherlands Publication: December 6, 2012
Imprint: Springer Language: English
Author: J. A. Whitesell
ISBN: 9789400931619
Publisher: Springer Netherlands
Publication: December 6, 2012
Imprint: Springer
Language: English

Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.

More books from Springer Netherlands

Cover of the book Landscape Modelling by J. A. Whitesell
Cover of the book Interpreted Languages and Compositionality by J. A. Whitesell
Cover of the book Visual Mathematics and Cyberlearning by J. A. Whitesell
Cover of the book Finalization in Science by J. A. Whitesell
Cover of the book Forms, Matter and Mind by J. A. Whitesell
Cover of the book Sustainable Cities and Military Installations by J. A. Whitesell
Cover of the book Machine Learning in Medicine by J. A. Whitesell
Cover of the book Animal models in cardiovascular research by J. A. Whitesell
Cover of the book Environmental Change in Lesotho by J. A. Whitesell
Cover of the book Historical Perspectives of Fisheries Exploitation in the Indo-Pacific by J. A. Whitesell
Cover of the book Phenomenology and the Human Positioning in the Cosmos by J. A. Whitesell
Cover of the book Safety in Offshore Drilling by J. A. Whitesell
Cover of the book Heat Transfer in Fluidized Beds by J. A. Whitesell
Cover of the book Second Language Teaching by J. A. Whitesell
Cover of the book A Collection of Polish Works on Philosophical Problems of Time and Spacetime by J. A. Whitesell
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy