Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules

Nonfiction, Science & Nature, Science, Chemistry, Clinical, Organic
Cover of the book Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules by Robert.J Sharpe, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Robert.J Sharpe ISBN: 9783319390253
Publisher: Springer International Publishing Publication: June 9, 2016
Imprint: Springer Language: English
Author: Robert.J Sharpe
ISBN: 9783319390253
Publisher: Springer International Publishing
Publication: June 9, 2016
Imprint: Springer
Language: English

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.

 

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.

 

More books from Springer International Publishing

Cover of the book Business Intelligence for New-Generation Managers by Robert.J Sharpe
Cover of the book Foundations of Circulation Control Based Small-Scale Unmanned Aircraft by Robert.J Sharpe
Cover of the book Mathematics Education in a Context of Inequity, Poverty and Language Diversity by Robert.J Sharpe
Cover of the book Security Privatization by Robert.J Sharpe
Cover of the book Advances in Evolutionary and Deterministic Methods for Design, Optimization and Control in Engineering and Sciences by Robert.J Sharpe
Cover of the book Progress in Ultrafast Intense Laser Science XI by Robert.J Sharpe
Cover of the book Parliamentarians’ Professional Development by Robert.J Sharpe
Cover of the book The International Political Economy of Oil and Gas by Robert.J Sharpe
Cover of the book Nonparametric Statistics by Robert.J Sharpe
Cover of the book Hospital Wastewaters by Robert.J Sharpe
Cover of the book Atlas of Ecosystem Services by Robert.J Sharpe
Cover of the book Advanced Intelligent Computational Technologies and Decision Support Systems by Robert.J Sharpe
Cover of the book New Frontiers in Mining Complex Patterns by Robert.J Sharpe
Cover of the book Behavioral Analysis of Maternal Filicide by Robert.J Sharpe
Cover of the book Text Linguistics and Classical Studies by Robert.J Sharpe
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy