Structural and Functional Characterization of the Immunoproteasome

Nonfiction, Science & Nature, Science, Chemistry, Analytic, Biological Sciences, Biochemistry
Cover of the book Structural and Functional Characterization of the Immunoproteasome by Eva Maria Huber, Springer International Publishing
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Author: Eva Maria Huber ISBN: 9783319015569
Publisher: Springer International Publishing Publication: September 16, 2013
Imprint: Springer Language: English
Author: Eva Maria Huber
ISBN: 9783319015569
Publisher: Springer International Publishing
Publication: September 16, 2013
Imprint: Springer
Language: English

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

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In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

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