Synthesis of new isatin derivatives for possible CNS activity

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Synthesis of new isatin derivatives for possible CNS activity by Kiran Gangarapu, GRIN Verlag
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Author: Kiran Gangarapu ISBN: 9783656622727
Publisher: GRIN Verlag Publication: March 25, 2014
Imprint: GRIN Verlag Language: English
Author: Kiran Gangarapu
ISBN: 9783656622727
Publisher: GRIN Verlag
Publication: March 25, 2014
Imprint: GRIN Verlag
Language: English

Master's Thesis from the year 2013 in the subject Medicine - Pharmacology, grade: 10, , course: M-Pharmacy, language: English, abstract: Isatin (1H-indole-2,3-dione) (I) was first discovered by Erdmann and Laurent in 1841, independently as a product from oxidation of indigo by nitric and chromic acids. It is a unique molecule possessing both amide and keto carbonyl groups. Apart from this, it has an active hydrogen atom attached to nitrogen (or oxygen) and an aromatic ring which was substituted at 5- and 7-positions. It exists in a tautomeric form (II) and these functional characteristics play an important role in governing the various reactions of the molecule. The C-3 carbonyl group of isatin is strongly electrophilic. As a result, isatins are readily involved in condensation and addition reactions with carbanion type nucleophiles into 3-substituted oxindoles. In general, there are three possibilities during condensation reactions. [...]

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Master's Thesis from the year 2013 in the subject Medicine - Pharmacology, grade: 10, , course: M-Pharmacy, language: English, abstract: Isatin (1H-indole-2,3-dione) (I) was first discovered by Erdmann and Laurent in 1841, independently as a product from oxidation of indigo by nitric and chromic acids. It is a unique molecule possessing both amide and keto carbonyl groups. Apart from this, it has an active hydrogen atom attached to nitrogen (or oxygen) and an aromatic ring which was substituted at 5- and 7-positions. It exists in a tautomeric form (II) and these functional characteristics play an important role in governing the various reactions of the molecule. The C-3 carbonyl group of isatin is strongly electrophilic. As a result, isatins are readily involved in condensation and addition reactions with carbanion type nucleophiles into 3-substituted oxindoles. In general, there are three possibilities during condensation reactions. [...]

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