Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Nonfiction, Health & Well Being, Medical, Specialties, Oncology, Reference, Public Health
Cover of the book Targeting Cell Survival Pathways to Enhance Response to Chemotherapy by Daniel E. Johnson, Elsevier Science
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Author: Daniel E. Johnson ISBN: 9780128137543
Publisher: Elsevier Science Publication: March 28, 2018
Imprint: Academic Press Language: English
Author: Daniel E. Johnson
ISBN: 9780128137543
Publisher: Elsevier Science
Publication: March 28, 2018
Imprint: Academic Press
Language: English

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment.

Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

  • Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer
  • Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy
  • Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials
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Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment.

Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

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