Telomerases

Chemistry, Biology, and Clinical Applications

Nonfiction, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Telomerases by , Wiley
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Author: ISBN: 9781118267516
Publisher: Wiley Publication: May 22, 2012
Imprint: Wiley Language: English
Author:
ISBN: 9781118267516
Publisher: Wiley
Publication: May 22, 2012
Imprint: Wiley
Language: English

This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

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This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

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