The Aging Lungs

Mechanisms and Clinical Sequelae

This volume provides a comprehensive and multi-disciplinary overview of the aging lung, written by the main researchers in the field. Current physiological, cellular and molecular understanding of how the lungs age and the relationship to age-associated lung diseases will be presented. The contents are aimed at a broad audience of scientists and clinicians with an interest in the respiratory system, pathogenesis of age-associated lung diseases and clinical implications.

Contents:

• Normal Development, Anatomy, Histology and Aging of the Lung (Xuchen Zhang and Robert J Homer)
• Physiology of the Aging Lung (Brienne Miner, Thomas M Gill, and Carlos A Vaz Fragoso)
• Aging Lung, Environmental and Genetic Factors — Race, Ethnicity and Gender (Holly Keyt, Stephanie Levine, and Claude Jourdan Le Saux)
• Frailty in Pulmonary and Critical Care Medicine (Cristine E Berry and Enid R Neptune)
• Intensive Care Unit Outcomes in Older Adults (Margaret A Pisani and Lauren Ferrante)
• Severe Sepsis, Pneumonia and Aging (Olufunmilayo Falade and Sachin Yende)
• Sepsis and Acute Lung Injury in Aging (Anup Srivastava, Yao Wong, Shruti Erramilli, and Praveen Mannam)
• Acute Respiratory Distress Syndrome: The Role of Mesenchymal Stem Cells and Arising Complications Due to an Aging Lung (John Sembrat, Maria G Kapetanaki, and Mauricio Rojas)
• The Aging Immune System, Vaccine Efficacy, and the Lung (Jenna M Bartley and Laura Haynes)
• Respiratory Infection, Airway Colonization and Chronic Inflammation in Aging (Chad Marion and Charles S Dela Cruz)
• HIV, the Lung and Aging (Lynn M Schnapp and Kristina Crothers)
• Geriatric Pulmonary Hypertension: Recent Epidemiologic Trends and Treatment Update (Vanessa Yap, George A Kuchel, and Raymond J Foley)
• Growth Factors and Aging in Pulmonary Arterial Hypertension (Claudio Bravo, Won-Kyung Cho, and Hyung J Chun)
• Chronic Obstructive Lung Disease in the Elderly (Jessica F Most and Carolyn L Rochester)
• Genomics of Lung Aging and Idiopathic Pulmonary Fibrosis (Brenda Juan-Guardela and Naftali Kaminski)
• Potential Mechanistic Links Between Aging and IPF (Hongyi Pan, Mridu Gulati, and Erica L Herzog)
• Telomeres and Telomerase (Mary Armanios)
• Endoplasmic Reticulum Stress (Marta Bueno and Ana L Mora)
• Autophagy and Metabolism (Jaime L Schneider and Cecilia G Sanchez)

Readership: Graduate and post-graduate respiratory, pulmonary, thoracic scientists and physicians; Clinical researchers interested in both pulmonary and aging issues, medical students and professionals.
Key Features:

• Pre-eminent authors and researchers in their respective fields
• Comprehensive coverage of research, clinical and therapeutic considerations
• Cutting-edge biology and mechanisms included