The Biology of Oligodendrocytes

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Neuroscience, Science & Nature, Science
Cover of the book The Biology of Oligodendrocytes by , Cambridge University Press
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Author: ISBN: 9780511850745
Publisher: Cambridge University Press Publication: October 21, 2010
Imprint: Cambridge University Press Language: English
Author:
ISBN: 9780511850745
Publisher: Cambridge University Press
Publication: October 21, 2010
Imprint: Cambridge University Press
Language: English

Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.

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Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.

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