The Combinatorial Index

Nonfiction, Science & Nature, Science, Chemistry, Physical & Theoretical, Organic
Cover of the book The Combinatorial Index by Barry A. Bunin, Elsevier Science
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Author: Barry A. Bunin ISBN: 9780080542409
Publisher: Elsevier Science Publication: April 15, 1998
Imprint: Academic Press Language: English
Author: Barry A. Bunin
ISBN: 9780080542409
Publisher: Elsevier Science
Publication: April 15, 1998
Imprint: Academic Press
Language: English

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity.

  • Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods
  • Serves as a laboratory manual for bench chemists
  • Includes a chapter on linkers to assist in choice of linking strategy
  • Discusses strengths and limitations of the various methods
  • Contains a structural index showing functional group transformations in solid-phase synthesis
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With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity.

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