The Human T-Cell Receptor Repertoire and Transplantation

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology
Cover of the book The Human T-Cell Receptor Repertoire and Transplantation by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783662224946
Publisher: Springer Berlin Heidelberg Publication: June 29, 2013
Imprint: Springer Language: English
Author:
ISBN: 9783662224946
Publisher: Springer Berlin Heidelberg
Publication: June 29, 2013
Imprint: Springer
Language: English

these analyses it became clear that the MHC class I molecule com­ prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec­ tron-dense material in the groove. This material was subsequently iden­ 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu­ tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep­ tion of the DR a-chain, all other MHC class II a and 13 chains are poly­ morphic.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

these analyses it became clear that the MHC class I molecule com­ prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec­ tron-dense material in the groove. This material was subsequently iden­ 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu­ tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep­ tion of the DR a-chain, all other MHC class II a and 13 chains are poly­ morphic.

More books from Springer Berlin Heidelberg

Cover of the book Sprachverarbeitung und Sprachübertragung by
Cover of the book Chemie vermitteln by
Cover of the book Partnerschaftsqualität und kindliche Entwicklung by
Cover of the book Mathematical Modeling for Complex Fluids and Flows by
Cover of the book Alternative Dispute Resolution in European Administrative Law by
Cover of the book Betriebliche Gesundheitsförderung by
Cover of the book Electrogenerated Chemiluminescence by
Cover of the book Collaborative Design for Embedded Systems by
Cover of the book Genetics of the Epilepsies by
Cover of the book CSR und Nachhaltige Innovation by
Cover of the book Economics and the Interpretation and Application of U.S. and E.U. Antitrust Law by
Cover of the book Major Aspects of Chinese Religion and Philosophy by
Cover of the book Multiple Sclerosis by
Cover of the book Vertebrate Myogenesis by
Cover of the book The Subchondral Bone Plate by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy