The Th2 Type Immune Response in Health and Disease

From Host Defense and Allergy to Metabolic Homeostasis and Beyond

Nonfiction, Health & Well Being, Medical, Ailments & Diseases, Infectious Diseases, Parasitology, Medical Science, Immunology
Cover of the book The Th2 Type Immune Response in Health and Disease by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781493929115
Publisher: Springer New York Publication: December 8, 2015
Imprint: Springer Language: English
Author:
ISBN: 9781493929115
Publisher: Springer New York
Publication: December 8, 2015
Imprint: Springer
Language: English

The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.

More books from Springer New York

Cover of the book Introduction to the Mechanics of Deformable Solids by
Cover of the book Better Business Regulation in a Risk Society by
Cover of the book Cataract Surgery in the Glaucoma Patient by
Cover of the book Stem Cells and Tissue Engineering by
Cover of the book FPGA Design by
Cover of the book Pervasive Health Knowledge Management by
Cover of the book Non-coding RNAs and Cancer by
Cover of the book Linking Trade and Security by
Cover of the book Anthocyanins by
Cover of the book PET in the Evaluation of Alzheimer's Disease and Related Disorders by
Cover of the book Affect Regulation Training by
Cover of the book The Impacts of Research and Development Expenditures by
Cover of the book Pediatric Orthopedic Surgical Emergencies by
Cover of the book Hormone Resistance and Other Endocrine Paradoxes by
Cover of the book Internet Optical Infrastructure by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy