“Recent Emerging therapies for Multidrug Resistant (MDR) Acinetobacter baumannii ”

The global emergence of multidrug resistant Acinetobacter baumannii has reduced the number of clinically available antibiotics that retain activity against this pathogen.

For this reason, the development of novel prevention and treatment strategies for infections caused by A. baumannii is necessary.

       Several studies have begun to characterize nonantibiotic approaches that utilize novel mechanisms of action to achieve antibacterial activity.

They Include:

1.  Recent advances in phage therapy  

2. Antimicrobial peptides

3. Prophylactic vaccination

4. Photodynamic therapy

5. Iron chelation therapy

6. Nitric oxide (NO)-based therapies have all been shown to have activity against A. baumannii.

         However, before these approaches can be used clinically there are still limitations and remaining questions that must be addressed.

An attempt has been made to describe the above enumerated nanobiotic approaches in this booklet for my enthusiastic readers. 

 ........Dr. H.K.Saboowala.