Advances in Rapid Sex-Steroid Action

New Challenges and New Chances in Breast and Prostate Cancers

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Oncology
Cover of the book Advances in Rapid Sex-Steroid Action by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461417644
Publisher: Springer New York Publication: December 15, 2011
Imprint: Springer Language: English
Author:
ISBN: 9781461417644
Publisher: Springer New York
Publication: December 15, 2011
Imprint: Springer
Language: English

Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.

More books from Springer New York

Cover of the book Lecture Notes on the General Theory of Relativity by
Cover of the book Intra-Operative Neuropathology for the Non-Neuropathologist by
Cover of the book Next Generation Microchannel Heat Exchangers by
Cover of the book GI Endoscopic Emergencies by
Cover of the book Smoothing Spline ANOVA Models by
Cover of the book Surgery by
Cover of the book Reviews of Environmental Contamination and Toxicology by
Cover of the book Distributed Space Missions for Earth System Monitoring by
Cover of the book Topics in Statistical Simulation by
Cover of the book Contemporary Methods for Speech Parameterization by
Cover of the book Strategies for Urban Development in Leipzig, Germany by
Cover of the book Frontiers in Cancer Research by
Cover of the book Options in the Management of the Open Abdomen by
Cover of the book Ultra-Wideband, Short Pulse Electromagnetics 9 by
Cover of the book Studies in Diabetes by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy