Advances in Rapid Sex-Steroid Action

New Challenges and New Chances in Breast and Prostate Cancers

Nonfiction, Health & Well Being, Medical, Specialties, Internal Medicine, Endocrinology & Metabolism, Oncology
Cover of the book Advances in Rapid Sex-Steroid Action by , Springer New York
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9781461417644
Publisher: Springer New York Publication: December 15, 2011
Imprint: Springer Language: English
Author:
ISBN: 9781461417644
Publisher: Springer New York
Publication: December 15, 2011
Imprint: Springer
Language: English

Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.

More books from Springer New York

Cover of the book The Helmholtz Equation Least Squares Method by
Cover of the book Patient Navigation by
Cover of the book Preventing Disease by
Cover of the book Pharmaceutical Suspensions by
Cover of the book Control of Linear Parameter Varying Systems with Applications by
Cover of the book Data Storage for Social Networks by
Cover of the book Telephone and Helpdesk Skills by
Cover of the book Differential Diagnosis in Pediatrics by
Cover of the book Nanomedicine by
Cover of the book Ordinary Differential Equations by
Cover of the book Emerging Themes in Cognitive Development by
Cover of the book Understanding Statistics Using R by
Cover of the book Ethnic Differences in Fertility and Assisted Reproduction by
Cover of the book Bariatric Endoscopy by
Cover of the book Communications, Signal Processing, and Systems by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy