Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications by , Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9789400773592
Publisher: Springer Netherlands Publication: October 22, 2013
Imprint: Springer Language: English
Author:
ISBN: 9789400773592
Publisher: Springer Netherlands
Publication: October 22, 2013
Imprint: Springer
Language: English

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

More books from Springer Netherlands

Cover of the book Physical Properties of Materials by
Cover of the book Biology, Controls and Models of Tree Volatile Organic Compound Emissions by
Cover of the book Biotechnology of Neglected and Underutilized Crops by
Cover of the book Emmanuel Levinas by
Cover of the book The Pacemaker Clinic of the 90’s by
Cover of the book Engineering Behaviour of Rocks by
Cover of the book Machines and Signs by
Cover of the book What’s New in Anesthesiology by
Cover of the book The Light of the Night Sky by
Cover of the book Economics of Cooperative Farming by
Cover of the book Collected Courses of the Academy of European Law / Recueil des cours de l’ Académie de droit européen by
Cover of the book Artificial Structures and Shorelines by
Cover of the book Origin(s) of Design in Nature by
Cover of the book Stem Cells in Cancer: Should We Believe or Not? by
Cover of the book Non-Destructive Assessment of Concrete Structures: Reliability and Limits of Single and Combined Techniques by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy