Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides

Nonfiction, Science & Nature, Science, Biological Sciences, Biochemistry, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides by David A. Hopwood, Elsevier Science
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: David A. Hopwood ISBN: 9780080923352
Publisher: Elsevier Science Publication: April 10, 2009
Imprint: Academic Press Language: English
Author: David A. Hopwood
ISBN: 9780080923352
Publisher: Elsevier Science
Publication: April 10, 2009
Imprint: Academic Press
Language: English

Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine.

* Gathers tried and tested methods and techniques from top players in the field.
* In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides.
* Provides an extremely useful reference for the experienced research scientist.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine.

* Gathers tried and tested methods and techniques from top players in the field.
* In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides.
* Provides an extremely useful reference for the experienced research scientist.

More books from Elsevier Science

Cover of the book Neuropsychopharmacology: A Tribute to Joseph T. Coyle by David A. Hopwood
Cover of the book The Comprehensive Sourcebook of Bacterial Protein Toxins by David A. Hopwood
Cover of the book Current Developments in Biotechnology and Bioengineering by David A. Hopwood
Cover of the book Informatics for Materials Science and Engineering by David A. Hopwood
Cover of the book The Globalisation of Executives and Economies by David A. Hopwood
Cover of the book Kinetics of Aggregation and Gelation by David A. Hopwood
Cover of the book Multiple Sclerosis by David A. Hopwood
Cover of the book Neurobiology of Psychiatric Disorders by David A. Hopwood
Cover of the book Topical Reviews in Neurosurgery by David A. Hopwood
Cover of the book Advances in Agronomy by David A. Hopwood
Cover of the book Advances in Crystals and Elastic Metamaterials, Part 1 by David A. Hopwood
Cover of the book Introduction to Probability Models by David A. Hopwood
Cover of the book Graduate Research by David A. Hopwood
Cover of the book Handbook of Measure Theory by David A. Hopwood
Cover of the book The Psychology of Learning and Motivation by David A. Hopwood
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy