Genetics of the Mouse

Nonfiction, Health & Well Being, Medical, Medical Science, Genetics, Science & Nature, Science, Biological Sciences, Zoology
Cover of the book Genetics of the Mouse by Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli, Springer Berlin Heidelberg
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Author: Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli ISBN: 9783662442876
Publisher: Springer Berlin Heidelberg Publication: November 29, 2014
Imprint: Springer Language: English
Author: Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
ISBN: 9783662442876
Publisher: Springer Berlin Heidelberg
Publication: November 29, 2014
Imprint: Springer
Language: English

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.

 

The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.

 

In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

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This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.

 

The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.

 

In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

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