Immune Metabolism in Health and Tumor

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology, Science & Nature, Science, Biological Sciences, Biochemistry
Cover of the book Immune Metabolism in Health and Tumor by , Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9789402411706
Publisher: Springer Netherlands Publication: September 5, 2017
Imprint: Springer Language: English
Author:
ISBN: 9789402411706
Publisher: Springer Netherlands
Publication: September 5, 2017
Imprint: Springer
Language: English

This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients.

The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders.

This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients.

The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders.

This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.

More books from Springer Netherlands

Cover of the book Sustainability in the Chemical Industry by
Cover of the book Language and the Phenomenological Reductions of Edmund Husserl by
Cover of the book The Eukaryotic Replisome: a Guide to Protein Structure and Function by
Cover of the book The Practice of Theoretical Curiosity by
Cover of the book The Ecology of Urban Habitats by
Cover of the book III-Nitride Based Light Emitting Diodes and Applications by
Cover of the book Green Communications and Networks by
Cover of the book Young People’s Human Rights and the Politics of Voting Age by
Cover of the book Improving Quality Assurance in European Vocational Education and Training by
Cover of the book Microbial Mats by
Cover of the book Many Visions, Many Aims by
Cover of the book Dhaka Megacity by
Cover of the book Perspectives on Practice and Meaning in Mathematics and Science Classrooms by
Cover of the book Life Science Ethics by
Cover of the book Edmund Husserl’s Theory of Meaning by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy