Immunological Synapse

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology
Cover of the book Immunological Synapse by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642038587
Publisher: Springer Berlin Heidelberg Publication: December 3, 2009
Imprint: Springer Language: English
Author:
ISBN: 9783642038587
Publisher: Springer Berlin Heidelberg
Publication: December 3, 2009
Imprint: Springer
Language: English

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide–MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide– MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide–MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide– MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

More books from Springer Berlin Heidelberg

Cover of the book Soft Tissue Balancing in Total Knee Arthroplasty by
Cover of the book Malignant Mesothelioma by
Cover of the book China’s Macroeconomic Outlook by
Cover of the book PET-CT and PET-MRI in Oncology by
Cover of the book From Atom Optics to Quantum Simulation by
Cover of the book Quantile Regression for Spatial Data by
Cover of the book Dynamics of Magnetically Trapped Particles by
Cover of the book Axonal Regeneration in the Mammalian Central Nervous System by
Cover of the book Towards a Dynamic Regional Innovation System by
Cover of the book Organic Electronics by
Cover of the book Skin Carcinogenesis in Man and in Experimental Models by
Cover of the book Praxiskommentar zum Gesetz über die parlamentarische Kontrolle nachrichtendienstlicher Tätigkeit des Bundes by
Cover of the book NeuroPET by
Cover of the book Transactions on Computational Collective Intelligence XXIV by
Cover of the book Perspectives of System Informatics by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy