Immunological Synapse

Nonfiction, Health & Well Being, Medical, Medical Science, Immunology
Cover of the book Immunological Synapse by , Springer Berlin Heidelberg
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783642038587
Publisher: Springer Berlin Heidelberg Publication: December 3, 2009
Imprint: Springer Language: English
Author:
ISBN: 9783642038587
Publisher: Springer Berlin Heidelberg
Publication: December 3, 2009
Imprint: Springer
Language: English

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide–MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide– MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptide–MHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptide–MHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide– MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

More books from Springer Berlin Heidelberg

Cover of the book The Forgotten Revolution by
Cover of the book Pathogenic Yeasts by
Cover of the book Cancer Mapping by
Cover of the book Endocrine Treatment of Breast Cancer by
Cover of the book Gibt es einen "7. Sinn"? by
Cover of the book The Molecular Biology of Paget’s Disease by
Cover of the book Industrial Image Processing by
Cover of the book Customer Relationship Management in the Financial Industry by
Cover of the book Algorithms and Computation by
Cover of the book Enterprise Management with SAP SEM™ / Business Analytics by
Cover of the book Molecular Mechanisms of Resistance to Agrochemicals by
Cover of the book Erkrankungen des Pankreas by
Cover of the book Leading Pharmaceutical Innovation by
Cover of the book Introduction to Autonomous Manipulation by
Cover of the book Ultimate Explanations of the Universe by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy