Morphofunctional Aspects of Tumor Microcirculation

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Specialties, Oncology
Cover of the book Morphofunctional Aspects of Tumor Microcirculation by Domenico Ribatti, Springer Netherlands
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Domenico Ribatti ISBN: 9789400749368
Publisher: Springer Netherlands Publication: September 28, 2012
Imprint: Springer Language: English
Author: Domenico Ribatti
ISBN: 9789400749368
Publisher: Springer Netherlands
Publication: September 28, 2012
Imprint: Springer
Language: English

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

More books from Springer Netherlands

Cover of the book Open Multithreaded Transactions by Domenico Ribatti
Cover of the book Thin Films and Coatings in Biology by Domenico Ribatti
Cover of the book The Role of Biotechnology in Countering BTW Agents by Domenico Ribatti
Cover of the book Minority Languages and Multilingual Education by Domenico Ribatti
Cover of the book Virtuous Thoughts: The Philosophy of Ernest Sosa by Domenico Ribatti
Cover of the book Adapted Primary Literature by Domenico Ribatti
Cover of the book Mycobacterial Skin Diseases by Domenico Ribatti
Cover of the book Lighter than Air Robots by Domenico Ribatti
Cover of the book A Primer on Complex Systems by Domenico Ribatti
Cover of the book Storing Carbon in Agricultural Soils by Domenico Ribatti
Cover of the book Internal War and the Search for Normative Order by Domenico Ribatti
Cover of the book Teaching Africa by Domenico Ribatti
Cover of the book The Great Chain of Being and Italian Phenomenology by Domenico Ribatti
Cover of the book Information Technology Convergence by Domenico Ribatti
Cover of the book Studies in Text Grammar by Domenico Ribatti
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy