Phosphodiesterase Inhibitors

Nonfiction, Science & Nature, Science, Other Sciences, Molecular Biology, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Phosphodiesterase Inhibitors by Clive Page, Christian Schudt, Gordon Dent, Klaus F. Rabe, Elsevier Science
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Author: Clive Page, Christian Schudt, Gordon Dent, Klaus F. Rabe ISBN: 9780080538815
Publisher: Elsevier Science Publication: August 16, 1996
Imprint: Academic Press Language: English
Author: Clive Page, Christian Schudt, Gordon Dent, Klaus F. Rabe
ISBN: 9780080538815
Publisher: Elsevier Science
Publication: August 16, 1996
Imprint: Academic Press
Language: English

Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting.

  • Utilizes actual testing and research of new PDE inhibitors
  • Valuable for researchers and students alike
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Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting.

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