Planning and Analyzing Clinical Trials with Composite Endpoints

Nonfiction, Health & Well Being, Medical, Reference, Biostatistics, Science & Nature, Mathematics, Science, Biological Sciences
Cover of the book Planning and Analyzing Clinical Trials with Composite Endpoints by Geraldine Rauch, Svenja Schüler, Meinhard Kieser, Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Geraldine Rauch, Svenja Schüler, Meinhard Kieser ISBN: 9783319737706
Publisher: Springer International Publishing Publication: May 22, 2018
Imprint: Springer Language: English
Author: Geraldine Rauch, Svenja Schüler, Meinhard Kieser
ISBN: 9783319737706
Publisher: Springer International Publishing
Publication: May 22, 2018
Imprint: Springer
Language: English

This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful.

The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes required for fast and easy implementation are provided. The book also discusses all the methods in the context of relevant guidelines related to the topic. To benefit most from the book, readers should be familiar with the principles of clinical trials and basic statistical methods.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful.

The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes required for fast and easy implementation are provided. The book also discusses all the methods in the context of relevant guidelines related to the topic. To benefit most from the book, readers should be familiar with the principles of clinical trials and basic statistical methods.

More books from Springer International Publishing

Cover of the book Calculus Problems by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Complications of Regional Anesthesia by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Secondary Liability of Internet Service Providers by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book International Conference on Oriental Thinking and Fuzzy Logic by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Information and Communication Technologies for Ageing Well and e-Health by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Preventing Mental Illness by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Defending Culture by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Simulation Approach Towards Energy Flexible Manufacturing Systems by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Supply Chain Disruption Management Using Stochastic Mixed Integer Programming by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Sustainable Intensification to Advance Food Security and Enhance Climate Resilience in Africa by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Storm-triggered Landslides in Warmer Climates by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Geospatial Semantic Web by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Spaceports Around the World, A Global Growth Industry by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book From Particle Systems to Partial Differential Equations by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
Cover of the book Progress in the Chemistry of Organic Natural Products 108 by Geraldine Rauch, Svenja Schüler, Meinhard Kieser
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy