Structure and Action of Molecular Chaperones

Machines that Assist Protein Folding in the Cell

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Other Sciences, Molecular Biology
Cover of the book Structure and Action of Molecular Chaperones by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard, World Scientific Publishing Company
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard ISBN: 9789814749343
Publisher: World Scientific Publishing Company Publication: August 8, 2016
Imprint: WSPC Language: English
Author: Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
ISBN: 9789814749343
Publisher: World Scientific Publishing Company
Publication: August 8, 2016
Imprint: WSPC
Language: English

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

Contents:

  • Hsp70 Molecular Chaperones: Versatile Modular Nanomachines that Mediate Multiple Biological Functions (Lila M Gierasch)
  • Structural Analysis of GroEL/GroES Chaperone-Mediated Protein Folding (Arthur L Howrich)
  • Structural Analysis of Type II Chaperonins in Archaebacteria and the Eukaryotic Cytosol (Arthur L Howrich)
  • The Family of Small Heat Shock Proteins: Assembly and Binding Functions (C Slingsby and A R Clark)
  • Structure and Mechanism of AAA+ Chaperones (Shannon M Doyle, Andrea N Kravats and Sue Wickner)
  • Structural Insights into Hsp90 Function (Elaine Kirschke, Daniel Elnatan, Kliment Verba and David A Agard)

Readership: Cell and molecular biologists, biochemists and biophysicists, nanoscientists.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

Contents:

Readership: Cell and molecular biologists, biochemists and biophysicists, nanoscientists.

More books from World Scientific Publishing Company

Cover of the book Our Place in the Universe by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Plasma Research at the Limit by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Services Marketing by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Probing the Meaning of Quantum Mechanics by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book ITER Physics by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book The Noisy Oscillator by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Infinite-Dimensional Dynamical Systems in Atmospheric and Oceanic Science by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book BochnerRiesz Means on Euclidean Spaces by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book People's Livelihood in Contemporary China by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Particles and Quantum Fields by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Clinical Research Monitoring by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Frontiers in Applied Mechanics by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Theoretical Foundations for Quantitative Finance by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book Cost Analysis of Electronic Systems by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
Cover of the book The Singapore Ethnic Mosaic by Lila M Gierasch, Arthur L Horwich, Christine Slingsby;Sue Wickner;David Agard
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy