The Cellular Secretome and Organ Crosstalk

Nonfiction, Science & Nature, Science, Biological Sciences, Cytology, Biology
Cover of the book The Cellular Secretome and Organ Crosstalk by Juergen Eckel, Elsevier Science
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Author: Juergen Eckel ISBN: 9780128097199
Publisher: Elsevier Science Publication: June 12, 2018
Imprint: Academic Press Language: English
Author: Juergen Eckel
ISBN: 9780128097199
Publisher: Elsevier Science
Publication: June 12, 2018
Imprint: Academic Press
Language: English

The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease.

Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development.

  • Summarizes our current knowledge on the secretome of different cells and tissues
  • Dissects auto-, para- and endocrine functions of major secreted peptides and proteins
  • Analyzes the secretory malfunction of different cells and its impact for disease development
  • Authored by a leader in the field, presenting a coherent view on this very complex topic
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The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease.

Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development.

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