Thermodynamics and Kinetics of Drug Binding

Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Thermodynamics and Kinetics of Drug Binding by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Wiley
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Author: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ISBN: 9783527673056
Publisher: Wiley Publication: March 9, 2015
Imprint: Wiley-VCH Language: English
Author: Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
ISBN: 9783527673056
Publisher: Wiley
Publication: March 9, 2015
Imprint: Wiley-VCH
Language: English

This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects.
Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.

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This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects.
Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.

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