Uptake and Trafficking of Protein Toxins

Nonfiction, Health & Well Being, Medical, Medical Science, Microbiology, Pharmacology
Cover of the book Uptake and Trafficking of Protein Toxins by , Springer International Publishing
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: ISBN: 9783319588933
Publisher: Springer International Publishing Publication: December 1, 2017
Imprint: Springer Language: English
Author:
ISBN: 9783319588933
Publisher: Springer International Publishing
Publication: December 1, 2017
Imprint: Springer
Language: English

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

More books from Springer International Publishing

Cover of the book Dynamics of Partial Differential Equations by
Cover of the book Electromagnetic Foundations of Solar Radiation Collection by
Cover of the book ModelEd, TestEd, TrustEd by
Cover of the book Computations with Modular Forms by
Cover of the book Databases Theory and Applications by
Cover of the book Science, Museums and Collecting the Indigenous Dead in Colonial Australia by
Cover of the book Nonlinear Dynamics, Volume 1 by
Cover of the book Air Flow Management in Raised Floor Data Centers by
Cover of the book Community-Based Forest Management (CBFM) in Bangladesh by
Cover of the book Short Fibre Reinforced Cementitious Composites and Ceramics by
Cover of the book The Holy Spirit and Christian Formation by
Cover of the book CMOS Front Ends for Millimeter Wave Wireless Communication Systems by
Cover of the book Performative Experience Design by
Cover of the book The Mystery of the Seven Spheres by
Cover of the book Information and Communication Technologies in Education, Research, and Industrial Applications by
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy